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He is known to be lactose intolerant, and is also known for playing the cello.

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He shares an apartment in Pasadena with friend and fellow physicist Dr. Sheldon has a deep love and interest for science fiction and comic books, to the point of an obsession, and shows particular affinity for Spock, a fictional character from the Star Trek franchise.

He usually wears clothing emblazoned with logos for these interests as well as science-related designs.

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The American television sitcom The Big Bang Theory, created and executive produced by Chuck Lorre and Bill Prady, premiered on CBS on September 24, 2007.

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